Biology:2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
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Short description: Class of enzymes
| 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.312 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (EC 1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+
Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.
References
- ↑ "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry 83 (4): 1125–34. April 1978. PMID 26671.
- ↑ "Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry 86 (6): 1671–7. December 1979. PMID 528534.
- ↑ "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". Journal of Biochemistry 93 (2): 557–65. February 1983. PMID 6841353.
- ↑ "Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6". Journal of Bacteriology 182 (23): 6651–8. December 2000. doi:10.1128/jb.182.23.6651-6658.2000. PMID 11073908.
External links
- 2-hydroxy-4-carboxymuconate+semialdehyde+hemiacetal+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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