Biology:2-hydroxyglutarate synthase
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Short description: Class of enzymes
| 2-hydroxyglutarate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.3.11 | ||||||||
| CAS number | 9024-02-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2-hydroxyglutarate synthase (EC 2.3.3.11) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The three substrates of this enzyme are glyoxylic acid, propanoyl-CoA, and water. Its products are α-hydroxyglutaric acid and coenzyme A.[1]
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming). Other names in common use include 2-hydroxyglutaratic synthetase, 2-hydroxyglutaric synthetase, alpha-hydroxyglutarate synthase, hydroxyglutarate synthase, and 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating).[2]
See also
- D2HGDH
- L2HGDH
- 2-hydroxyglutarate dehydrogenase
- 2-Hydroxyglutaric aciduria
- Hydroxyacid-oxoacid transhydrogenase
References
- ↑ "Alpha-hydroxyglutaric acid synthetase". Journal of Bacteriology 84 (1): 186–7. July 1962. doi:10.1128/jb.84.1.186-187.1962. PMID 14491016.
- ↑ Enzyme 2.3.3.11 at KEGG Pathway Database.
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