Biology:Hydroxyacid-oxoacid transhydrogenase

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hydroxyacid-oxoacid transhydrogenase
Identifiers
EC number1.1.99.24
CAS number117698-31-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) is an enzyme that catalyzes the chemical reaction

  1. REDIRECT Template:Chemical reaction

The two substrates of this enzyme are (S)-3-hydroxybutyric acid and α-ketoglutaric acid. Its products are acetoacetic acid and (R)-2-hydroxyglutaric acid.[1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase. This enzyme is also called transhydrogenase, hydroxy acid-oxo acid.[2]

See also

References

  1. ↑ Enzyme 1.1.99.24 at KEGG Pathway Database.
  2. ↑ "Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria". J. Biol. Chem. 263 (32): 16872–9. 1988. doi:10.1016/S0021-9258(18)37472-6. PMID 3182820.