Biology:2-oxoadipate reductase
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Short description: Class of enzymes
| 2-oxoadipate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.172 | ||||||||
| CAS number | 61116-21-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-oxoadipate reductase (EC 1.1.1.172) is an enzyme that catalyzes the chemical reaction
- 2-hydroxyadipate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxoadipate + NADH + H+
Thus, the two substrates of this enzyme are 2-hydroxyadipate and NAD+, whereas its 3 products are 2-oxoadipate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-hydroxyadipate:NAD+ 2-oxidoreductase. Other names in common use include 2-ketoadipate reductase, alpha-ketoadipate reductase, and 2-ketoadipate reductase.
References
- "Purification and properties of alpha-ketoadipate reductase, a newly discovered enzyme from human placenta". Arch. Biochem. Biophys. 176 (2): 610–20. 1976. doi:10.1016/0003-9861(76)90205-8. PMID 185965.
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