Biology:25-hydroxycholesterol 7α-hydroxylase
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Short description: Class of enzymes
| 25-hydroxycholesterol 7alpha-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.100 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
25-hydroxycholesterol 7alpha-hydroxylase (EC 1.14.13.100, 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase) is an enzyme with systematic name cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
- (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450).
See also
- cholesterol;
- 25-hydroxycholesterol.
References
- ↑ "7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase". European Journal of Biochemistry 224 (2): 309–16. September 1994. doi:10.1111/j.1432-1033.1994.00309.x. PMID 7925343.
- ↑ "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". The Journal of Biological Chemistry 275 (22): 16543–9. June 2000. doi:10.1074/jbc.M001810200. PMID 10748047.
- ↑ "Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat". Metabolism 52 (5): 636–42. May 2003. doi:10.1053/meta.2003.50106. PMID 12759897.
- ↑ "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry 72: 137–74. 2003. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
External links
- 25-hydroxycholesterol+7alpha-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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