Biology:3,9-dihydroxypterocarpan 6a-monooxygenase
| 3,9-dihydroxypterocarpan 6a-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.14.93 | ||||||||
| CAS number | 92584-16-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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3,9-dihydroxypterocarpan 6a-monooxygenase (EC 1.14.14.93) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The four substrates of this enzyme are (6aR,11aR)-3,9-dihydroxypterocarpan, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are glycinol, oxidised NADP+, and water.[1][2]
3,9-dihydroxypterocarpan 6a-monooxygenase is a cytochrome P450 protein containing heme. It requires a partner, cytochrome P450 reductase which uses NADPH, for functional expression. The systematic name of this enzyme class is (6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating). Other names in common use include 3,9-dihydroxypterocarpan 6a-hydroxylase, and 3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous).[1] It is part of the biosynthetic pathway to phytoalexins in soybean.[3]
References
- ↑ 1.0 1.1 Enzyme 1.14.14.93 at KEGG Pathway Database.
- ↑ "Induction of phytoalexin synthesis in soybean. Stereospecific 3,9-dihydroxypterocarpan 6a-hydroxylase from elicitor-induced soybean cell cultures". European Journal of Biochemistry 142 (1): 127–31. July 1984. doi:10.1111/j.1432-1033.1984.tb08259.x. PMID 6540173.
- ↑ Schopfer, Christel R.; Kochs, Georg; Lottspeich, Friedrich; Ebel, Jürgen (1998). "Molecular characterization and functional expression of dihydroxypterocarpan 6a-hydroxylase, an enzyme specific for pterocarpanoid phytoalexin biosynthesis in soybean ( Glycine max L.)". FEBS Letters 432 (3): 182–186. doi:10.1016/S0014-5793(98)00866-7. PMID 9720921.
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