Biology:3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase

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Short description: Class of enzymes
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Identifiers
EC number1.14.14.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction:

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O

This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.

References

External links