Biology:3-dehydro-L-gulonate 2-dehydrogenase
| 3-dehydro-L-gulonate 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC number | 1.1.1.130 | ||||||||
| CAS number | 37250-61-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) is an enzyme that catalyzes the chemical reaction:
- 3-dehydro-L-gulonate + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+
The 3 substrates of this enzyme are 3-dehydro-L-gulonate, NAD+, and NADP+, whereas its 4 products are (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
References
- "beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid". J. Biol. Chem. 237: 2454–7. 1962. PMID 13926592.
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