Biology:3-dehydro-L-gulonate 2-dehydrogenase
| 3-dehydro-L-gulonate 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC number | 1.1.1.130 | ||||||||
| CAS number | 37250-61-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) is an enzyme that catalyzes the chemical reaction:
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme are 3-dehydro-L-gulonic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2,3-diketogulonic acid, reduced NADH, and a proton. The enzyme can also use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
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