Biology:3beta-hydroxy-5alpha-steroid dehydrogenase
From HandWiki
Short description: Enzyme
| 3β-hydroxy-5α-steroid dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.278 | ||||||||
| CAS number | 9015-81-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3β-hydroxy-5α-steroid dehydrogenase (EC 1.1.1.278) is an enzyme that catalyzes the chemical reaction
- 3β-hydroxy-5α-pregnane-20-one + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 5α-pregnan-3,20-dione + NADPH + H+
Thus, the two substrates of this enzyme are 3β-hydroxy-5α-pregnane-20-one (allopregnanolone) and NADP+, whereas its 3 products are 5α-pregnan-3,20-dione, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3β-hydroxy-5α-steroid:NADP+ 3-oxidoreductase.
References
- Lindemann P; Luckner M (1997). "Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata". Phytochemistry 46 (3): 507–513. doi:10.1016/S0031-9422(97)00315-4.
- "3 beta-hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH". Z. Naturforsch. C 45 (9–10): 963–72. 1990. PMID 2291772.
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