Biology:3beta-hydroxy-5beta-steroid dehydrogenase
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Short description: Enzyme
| 3beta-hydroxy-5beta-steroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.277 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, 3beta-hydroxy-5beta-steroid dehydrogenase (EC 1.1.1.277) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme are epipregnanolone and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are 5β-dihydroprogesterone, reduced NADPH, and a proton.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase. Other names in common use include 3beta-hydroxysteroid 5beta-oxidoreductase, and 3beta-hydroxysteroid 5beta-progesterone oxidoreductase.
References
- ↑ Enzyme 1.1.1.277 at KEGG Pathway Database.
- ↑ "Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata". Plant Physiol. Biochem. 34: 85–91. 1996.
- ↑ "Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea". Plant Cell 38 (2–3): 337–344. 1994. doi:10.1007/bf00033894. Bibcode: 1994PCTOC..38..337S.
- ↑ "Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata". Phytochemistry 46 (3): 507–513. 1997. doi:10.1016/S0031-9422(97)00315-4. Bibcode: 1997PChem..46..507L.
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