Biology:3beta-hydroxy-5beta-steroid dehydrogenase
From HandWiki
Short description: Enzyme
| 3beta-hydroxy-5beta-steroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.277 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a 3beta-hydroxy-5beta-steroid dehydrogenase (EC 1.1.1.277) is an enzyme that catalyzes the chemical reaction
- 3beta-hydroxy-5beta-pregnane-20-one + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 5beta-pregnan-3,20-dione + NADPH + H+
Thus, the two substrates of this enzyme are 3beta-hydroxy-5beta-pregnane-20-one and NADP+, whereas its 3 products are 5beta-pregnan-3,20-dione, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase. Other names in common use include 3beta-hydroxysteroid 5beta-oxidoreductase, and 3beta-hydroxysteroid 5beta-progesterone oxidoreductase.
References
- "Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata". Plant Physiol. Biochem. 34: 85–91. 1996.
- "Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea". Plant Cell 38: 337–344. 1994. doi:10.1007/bf00033894.
- "Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata". Phytochemistry 46 (3): 507–513. 1997. doi:10.1016/S0031-9422(97)00315-4.
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