Biology:Bilirubin-glucuronoside glucuronosyltransferase
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Short description: Class of enzymes
| bilirubin-glucuronoside glucuronosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.95 | ||||||||
| CAS number | 71822-22-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a bilirubin-glucuronoside glucuronosyltransferase (EC 2.4.1.95) is an enzyme that catalyzes the chemical reaction
- 2 bilirubin-glucuronoside [math]\displaystyle{ \rightleftharpoons }[/math] bilirubin + bilirubin-bisglucuronoside
Hence, this enzyme has one substrate, bilirubin-glucuronoside, and two products, bilirubin and bilirubin-bisglucuronoside.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase. Other names in common use include bilirubin monoglucuronide transglucuronidase, and bilirubin glucuronoside glucuronosyltransferase.
References
- "Enzymatic conversion of bilirubin monoglucuronide to diglucuronide by rat liver plasma membranes". J. Biol. Chem. 252 (8): 2710–6. 1977. doi:10.1016/S0021-9258(17)40517-5. PMID 15996.
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