Biology:Bleomycin hydrolase
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.[1][2][3]
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone.[4] Another of its activities is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.[3]
Interactions
BLMH has been shown to interact with RPL29,[5] RPL11,[5] UBE2I[6] and Amyloid precursor protein.[7]
References
- ↑ "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase". J Biol Chem 272 (52): 33298–304. January 1998. doi:10.1074/jbc.272.52.33298. PMID 9407121.
- ↑ "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase". Cancer Res 57 (19): 4191–5. October 1997. PMID 9331073.
- ↑ 3.0 3.1 "Entrez Gene: BLMH bleomycin hydrolase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=642.
- ↑ Jarosław Zimny; Marta Sikora; Andrzej Guranowski; Hieronim Jakubowski (2006). "Protective Mechanisms against Homocysteine Toxicity". The Journal of Biological Chemistry 281 (32): 22485–22492. doi:10.1074/jbc.M603656200. PMID 16769724. http://www.jbc.org/content/281/32/22485.abstract.
- ↑ 5.0 5.1 Koldamova, R P; Lefterov I M; DiSabella M T; Almonte C; Watkins S C; Lazo J S (June 1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry (UNITED STATES) 38 (22): 7111–7. doi:10.1021/bi990135l. ISSN 0006-2960. PMID 10353821.
- ↑ Koldamova, R P; Lefterov I M; DiSabella M T; Lazo J S (December 1998). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. (UNITED STATES) 54 (6): 954–61. doi:10.1124/mol.54.6.954. ISSN 0026-895X. PMID 9855622.
- ↑ Lefterov, I M; Koldamova R P; Lazo J S (September 2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. (UNITED STATES) 14 (12): 1837–47. doi:10.1096/fj.99-0938com. ISSN 0892-6638. PMID 10973933.
External links
- Human BLMH genome location and BLMH gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q13867 (Bleomycin hydrolase) at the PDBe-KB.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.". Cancer Res. 56 (8): 1746–50. 1996. PMID 8620487.
- "Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.". Biochemistry 35 (21): 6706–14. 1996. doi:10.1021/bi960092y. PMID 8639621.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Essential binding and functional domains of human bleomycin hydrolase.". Biochemistry 37 (8): 2282–90. 1998. doi:10.1021/bi9722204. PMID 9485374.
- "Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease.". Nat. Genet. 18 (3): 211–2. 1998. doi:10.1038/ng0398-211. PMID 9500538.
- "The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.". Cell 93 (1): 103–9. 1998. doi:10.1016/S0092-8674(00)81150-2. PMID 9546396.
- "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9.". Mol. Pharmacol. 54 (6): 954–61. 1999. doi:10.1124/mol.54.6.954. PMID 9855622.
- "Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin.". Arch. Dermatol. Res. 291 (4): 238–40. 1999. doi:10.1007/s004030050400. PMID 10335922.
- "Human bleomycin hydrolase binds ribosomal proteins.". Biochemistry 38 (22): 7111–7. 1999. doi:10.1021/bi990135l. PMID 10353821.
- "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.". Structure 7 (6): 619–27. 1999. doi:10.1016/S0969-2126(99)80083-5. PMID 10404591.
- "Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains.". Neurosci. Lett. 281 (1): 37–40. 2000. doi:10.1016/S0304-3940(00)00802-8. PMID 10686410.
- "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.". FASEB J. 14 (12): 1837–47. 2000. doi:10.1096/fj.99-0938com. PMID 10973933.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]". Ann. Biol. Clin. (Paris) 61 (1): 61–7. 2003. PMID 12604387.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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