Biology:Caspase-2
From HandWiki
Caspase-2 (EC 3.4.22.55, ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated protein 2, CASP-2, NEDD2 protein) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-
Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
References
- ↑ "Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme". Genes & Development 8 (14): 1613–26. July 1994. doi:10.1101/gad.8.14.1613. PMID 7958843.
- ↑ "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death". Cell 78 (5): 739–50. September 1994. doi:10.1016/S0092-8674(94)90422-7. PMID 8087842.
- ↑ "Activation of caspase-2 in apoptosis". The Journal of Biological Chemistry 272 (34): 21010–7. August 1997. doi:10.1074/jbc.272.34.21010. PMID 9261102.
- ↑ "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis". The Journal of Cell Biology 149 (3): 603–12. May 2000. doi:10.1083/jcb.149.3.603. PMID 10791974.
- ↑ "Caspase-2 function in response to DNA damage". Biochemical and Biophysical Research Communications 331 (3): 859–67. June 2005. doi:10.1016/j.bbrc.2005.03.191. PMID 15865942.
- ↑ "Proteases for cell suicide: functions and regulation of caspases". Microbiology and Molecular Biology Reviews 64 (4): 821–46. December 2000. doi:10.1128/mmbr.64.4.821-846.2000. PMID 11104820.
External links
- Caspase-2 at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
