Biology:Chlorophyllide a reductase
| Chlorophyllide a reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.7.15 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Chlorophyllide a reductase (EC 1.3.7.15), also known as COR, is an enzyme with systematic name bacteriochlorophyllide-a:ferredoxin 7,8-oxidoreductase.[1][2] It catalyses the following chemical reaction
- chlorophyllide a + 2 reduced ferredoxin + ATP + H2O + 2 H+ [math]\displaystyle{ \rightleftharpoons }[/math] 3-deacetyl 3-vinylbacteriochlorophyllide a + 2 oxidized ferredoxin + ADP + phosphate
- Structure of the substrate and product of the enzyme
Chlorophyllide a
Bacteriochlorophyllide a (R=H). The product of COR retains the vinyl group of the substrate in place of the acetyl group shown
This reduction (with trans stereochemistry) of the pyrrole ring B, gives the characteristic 18-electron aromatic system that distinguishes bacteriochlorophylls from chlorophylls, which retain the chlorin system of Chlorophyllide a. This enzyme is present in purple bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides, and Pseudomonadota. It is a component of the biosynthetic pathway to bacteriochlorophylls.[3][4][5]
See also
References
- ↑ Harada, Jiro; Mizoguchi, Tadashi; Tsukatani, Yusuke; Yokono, Makio; Tanaka, Ayumi; Tamiaki, Hitoshi (2014). "Chlorophyllide a Oxidoreductase Works as One of the Divinyl Reductases Specifically Involved in Bacteriochlorophyll a Biosynthesis". Journal of Biological Chemistry 289 (18): 12716–12726. doi:10.1074/jbc.M113.546739. PMID 24637023.
- ↑ Tsukatani, Yusuke; Harada, Jiro; Nomata, Jiro; Yamamoto, Haruki; Fujita, Yuichi; Mizoguchi, Tadashi; Tamiaki, Hitoshi (2015). "Rhodobacter sphaeroides mutants overexpressing chlorophyllide a oxidoreductase of Blastochloris viridis elucidate functions of enzymes in late bacteriochlorophyll biosynthetic pathways". Scientific Reports 5: 9741. doi:10.1038/srep09741. PMID 25978726. Bibcode: 2015NatSR...5E9741T.
- ↑ R. Caspi (2015-12-08). "Pathway: bacteriochlorophyll a biosynthesis". MetaCyc Metabolic Pathway Database. https://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5526. Retrieved 2020-06-04.
- ↑ "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports 20 (3): 327–41. June 2003. doi:10.1039/B110549N. PMID 12828371.
- ↑ "Recent advances in chlorophyll biosynthesis". Photosynthesis Research 90 (2): 173–94. November 2006. doi:10.1007/s11120-006-9076-6. PMID 17370354.
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