Biology:Cholesterol 25-hydroxylase
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Short description: Class of enzymes
| Cholesterol 25-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.99.38 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cholesterol 25-hydroxylase (EC 1.14.99.38) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The three substrates of this enzyme are cholesterol, a reduced electron acceptor, and oxygen. Its products are 25-hydroxycholesterol, the electron acceptor, and water.[1][2]
This enzyme is an oxidoreductase, that uses molecular oxygen as oxidant and contains a di-iron (Fe-O-Fe) cofactor.[3] The systematic name of this enzyme class is cholesterol, hydrogen-donor:oxygen oxidoreductase (25-hydroxylating). It is also called cholesterol 25-monooxygenase.[4]
Transcripts for this enzyme have been identified in macrophages from the testis.[5][6]
References
- ↑ "cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism". The Journal of Biological Chemistry 273 (51): 34316–27. December 1998. doi:10.1074/jbc.273.51.34316. PMID 9852097.
- ↑ "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry 72: 137–74. 2003. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
- ↑ "Resonance Raman evidence for an Fe-O-Fe center in stearoyl-ACP desaturase. Primary sequence identity with other diiron-oxo proteins". Biochemistry 33 (43): 12776–86. November 1994. doi:10.1021/bi00209a008. PMID 7947683.
- ↑ Enzyme 1.14.99.38 at KEGG Pathway Database.
- ↑ "25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro". Biology of Reproduction 66 (5): 1336–41. May 2002. doi:10.1095/biolreprod66.5.1336. PMID 11967195.
- ↑ "Testosterone regulates 25-hydroxycholesterol production in testicular macrophages". Biology of Reproduction 67 (5): 1435–8. November 2002. doi:10.1095/biolreprod.102.007575. PMID 12390873.
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