Biology:Coprococcus
Coprococcus is a genus of obligately anaerobic, nonmotile, Gram-positive cocci that are part of the human and animal gut microbiota.[1]
Coprococcus spp. are notable for their ability to ferment dietary fibers into short-chain fatty acids, especially butyrate, which is a key metabolite that supports colonocyte health, enhances mucosal integrity, and has anti-inflammatory properties. The genus is considered an important contributor to colonic homeostasis and overall gut health.[2]
Depletion of Coprococcus has been reported in patients with colorectal cancer, although a direct protective role remains to be fully established.[3]
One species, Coprococcus comes, may also influence the efficacy of blood pressure-lowering medications by modifying gut metabolism of esterified angiotensin-converting enzyme (ACE) inhibitors.[4]
Phylogeny
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[5] and the National Center for Biotechnology Information (NCBI)[6]
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Additional species placed elsewhere in LTP and GTDB phylogenies:
- Coprococcus catus Holdeman and Moore 1974
- Coprococcus comes Holdeman and Moore 1974
- "Coprococcus phoceensis" Bonnet et al. 2019
Etymology
From Ancient Greek:
- kopros – excrement, faeces
- kokkos – berry
→ Coprococcus – faecal coccus
See also
References
- ↑ Holdeman, L. V.; Moore, W. E. C. (1974). "New Genus, Coprococcus, Twelve New Species, and Emended Descriptions of Four Previously Described Species of Bacteria from Human Feces". International Journal of Systematic Bacteriology 24 (2): 260–277. doi:10.1099/00207713-24-2-260.
- ↑ Louis, Petia; Flint, Harry J. (2017). "Formation of propionate and butyrate by the human colonic microbiota". Environmental Microbiology 19 (1): 29–41. doi:10.1111/1462-2920.13589. PMID 27235414.
- ↑ Xia, Li C.; Liu, Gang; Gao, Yingxin; Li, Xiaoxin; Pan, Hongfei; Ai, Dongmei (2019). "Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model" (in English). Frontiers in Microbiology 10: 826. doi:10.3389/fmicb.2019.00826. ISSN 1664-302X. PMID 31068913.
- ↑ Yang et al. (2022). Identification of a gut commensal that compromises the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors. https://doi.org/10.1161/HYPERTENSIONAHA.121.18711. Hypertension. 2022;79:1591–1601.
- ↑ A.C. Parte. "Coprococcus". List of Prokaryotic names with Standing in Nomenclature (LPSN). https://lpsn.dsmz.de/genus/coprococcus.
- ↑ Sayers. "Coprococcus". National Center for Biotechnology Information (NCBI) taxonomy database. https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Undef&id=33042&lvl=3&keep=1&srchmode=1&unlock.
- ↑ "The LTP". https://imedea.uib-csic.es/mmg/ltp/#LTP.
- ↑ "LTP_all tree in newick format". https://imedea.uib-csic.es/mmg/ltp/wp-content/uploads/ltp/LTP_all_10_2024.ntree.
- ↑ "LTP_10_2024 Release Notes". https://imedea.uib-csic.es/mmg/ltp/wp-content/uploads/ltp/LTP_10_2024_release_notes.pdf.
- ↑ "GTDB release 09-RS220". https://gtdb.ecogenomic.org/about#4%7C.
- ↑ "bac120_r220.sp_labels". https://data.gtdb.ecogenomic.org/releases/release220/220.0/auxillary_files/bac120_r220.sp_labels.tree.
- ↑ "Taxon History". https://gtdb.ecogenomic.org/taxon_history/.
Wikidata ☰ Q3693215 entry
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