Biology:D-inositol-3-phosphate glycosyltransferase

From HandWiki
Short description: Class of enzymes
D-inositol-3-phosphate glycosyltransferase
Identifiers
EC number2.4.1.250
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

D-inositol-3-phosphate glycosyltransferase (EC 2.4.1.250, mycothiol glycosyltransferases, MshA) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

This enzyme catalyses the first dedicated reaction in the biosynthesis of mycothiol.

References

  1. "The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)". Journal of Bacteriology 185 (11): 3476–9. June 2003. doi:10.1128/JB.185.11.3476-3479.2003. PMID 12754249. 
  2. "Biochemistry of the initial steps of mycothiol biosynthesis". The Journal of Biological Chemistry 281 (45): 33910–20. November 2006. doi:10.1074/jbc.M604724200. PMID 16940050. 
  3. "Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis". The Journal of Biological Chemistry 283 (23): 15834–44. June 2008. doi:10.1074/jbc.M801017200. PMID 18390549. 

External links