Biology:Desosaminyl transferase EryCIII
From HandWiki
Short description: Enzyme
| Desosaminyl transferase EryCIII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.278 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Desosaminyl transferase EryCIII (EC 2.4.1.278, EryCIII) is an enzyme with systematic name dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B [math]\displaystyle{ \rightleftharpoons }[/math] dTDP + erythromycin D
The enzyme is involved in erythromycin biosynthesis.
References
- ↑ "In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides". Journal of the American Chemical Society 127 (41): 14128–9. October 2005. doi:10.1021/ja053704n. PMID 16218575.
- ↑ "Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway". Journal of the American Chemical Society 126 (32): 9924–5. August 2004. doi:10.1021/ja048836f. PMID 15303858.
- ↑ "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII". Journal of Molecular Biology 415 (1): 92–101. January 2012. doi:10.1016/j.jmb.2011.10.036. PMID 22056329.
External links
- Desosaminyl+transferase+EryCIII at the US National Library of Medicine Medical Subject Headings (MeSH)
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