Biology:Dolichyldiphosphatase

From HandWiki
Short description: Class of enzymes
dolichyldiphosphatase
Identifiers
EC number3.6.1.43
CAS number73361-26-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a dolichyldiphosphatase (EC 3.6.1.43) is an enzyme that catalyzes the chemical reaction

dolichyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] dolichyl phosphate + phosphate

Thus, the two substrates of this enzyme are dolichyl diphosphate and H2O, whereas its two products are dolichyl phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dolichyl-diphosphate phosphohydrolase. Other names in common use include dolichol diphosphatase, dolichyl pyrophosphatase, dolichyl pyrophosphate phosphatase, dolichyl diphosphate phosphohydrolase, and Dol-P-P phosphohydrolase. This enzyme participates in n-glycan biosynthesis.

References

  • "Two pathways of dephosphorylation of dolichyl diphosphate in yeasts". Biochemistry (Moscow) 50: 551–556.