Biology:Fucosylgalactoside 3-alpha-galactosyltransferase
| fucosylgalactoside 3-alpha-galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.37 | ||||||||
| CAS number | 37257-33-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a fucosylgalactoside 3-alpha-galactosyltransferase (EC 2.4.1.37) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R [math]\displaystyle{ \rightleftharpoons }[/math] UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R
Thus, the two substrates of this enzyme are UDP-galactose and alpha-L-fucosyl-(1->2)-D-galactosyl-R, whereas its two products are UDP and alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase. Other names in common use include UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose, alpha-D-galactosyltransferase, UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, 3-alpha-D-galactosyltransferase, [blood group substance] alpha-galactosyltransferase, blood-group substance B-dependent galactosyltransferase, glycoprotein-fucosylgalactoside alpha-galactosyltransferase, histo-blood group B transferase, and histo-blood substance B-dependent galactosyltransferase. This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1R7U, 1R7X, 1R80, 1R82, 2A8W, 2PGV, and 2PGY.
References
- "An α-d-galactosyltransferase associated with the blood-group B character". Biochem. J. 107 (5): 733–735. 1968. doi:10.1042/bj1070733. PMID 16742598.
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