Biology:GalNAc-alpha-(1-4)-GalNAc-alpha-(1-3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase
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Short description: Class of enzymes
| GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.292 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase (EC 2.4.1.292, PglH) is an enzyme with systematic name UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- 3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol [math]\displaystyle{ \rightleftharpoons }[/math] 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
This enzyme is solated from Campylobacter jejuni.
References
- ↑ "In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation". Proceedings of the National Academy of Sciences of the United States of America 102 (40): 14255–9. October 2005. doi:10.1073/pnas.0507311102. PMID 16186480. Bibcode: 2005PNAS..10214255G.
- ↑ "Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions". Biochemistry 48 (12): 2807–16. March 2009. doi:10.1021/bi802284d. PMID 19159314.
- ↑ "Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system". Proceedings of the National Academy of Sciences of the United States of America 108 (23): 9643–8. June 2011. doi:10.1073/pnas.1103321108. PMID 21606362. Bibcode: 2011PNAS..108.9643B.
External links
- >4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol%20alpha-1,4-N-acetyl-D-galactosaminyltransferase GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol+alpha-1,4-N-acetyl-D-galactosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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