Biology:Galactosylxylosylprotein 3-beta-galactosyltransferase
| galactosylxylosylprotein 3-beta-galactosyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.134 | ||||||||
| CAS number | 56626-21-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a galactosylxylosylprotein 3-beta-galactosyltransferase (EC 2.4.1.134) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein [math]\displaystyle{ \rightleftharpoons }[/math] UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
Thus, the two substrates of this enzyme are UDP-galactose and 4-beta-D-galactosyl-O-beta-D-xylosylprotein, whereas its two products are UDP and 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase. Other names in common use include galactosyltransferase II, and uridine diphosphogalactose-galactosylxylose galactosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.
References
- "Initiation of chondroitin sulphate synthesis by beta-D-galactosides Substrates for galactosyltransferase II". Biochem. J. 227 (3): 805–14. 1985. PMID 3924029.
- "Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans". J. Biol. Chem. 250 (13): 5200–7. 1975. PMID 1150655.
- "Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)". J. Biol. Chem. 276 (51): 48189–95. 2001. doi:10.1074/jbc.M107339200. PMID 11551958.
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