Biology:Inositol 2-dehydrogenase
| inositol 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.18 | ||||||||
| CAS number | 9028-25-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an inositol 2-dehydrogenase (EC 1.1.1.18) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme are myo-inositol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2,4,6/3,5-pentahydroxycyclohexanone, reduced NADH, and a proton.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is myo-inositol:NAD+ 2-oxidoreductase. Other names in common use include myo-inositol 2-dehydrogenase, myo-inositol:NAD+ oxidoreductase, inositol dehydrogenase, and myo-inositol dehydrogenase. This enzyme participates in inositol metabolism and inositol phosphate metabolism.
References
- ↑ Enzyme 1.1.1.18 at KEGG Pathway Database.
- ↑ "The pathway of myo-inositol degradation in Aerobacter aerogenes Dehydrogenation and dehydration". J. Biol. Chem. 241 (4): 800–6. 1966. doi:10.1016/S0021-9258(18)96836-5. PMID 5905122.
- ↑ "Inositol dehydrogenase from Aerobacter aerogenes". Arch. Biochem. Biophys. 60 (2): 352–63. 1956. doi:10.1016/0003-9861(56)90437-4. PMID 13292912.
- ↑ "Inositol dehydrogenase from the yeast Cryptococcus melibiosum". Biochim. Biophys. Acta 293 (2): 295–303. 1973. doi:10.1016/0005-2744(73)90337-9. PMID 4351258.
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