Biology:Ketosteroid monooxygenase
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Short description: Class of enzymes
| Ketosteroid monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.54 | ||||||||
| CAS number | 9044-53-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Ketosteroid monooxygenase (EC 1.14.13.54, steroid-ketone monooxygenase, progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)) is an enzyme with systematic name ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing).[1][2][3] This enzyme catalyses the following chemical reaction
- ketosteroid + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] steroid ester/lactone + NADP+ + H2O (general reaction)
- (1) progesterone + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] testosterone acetate + NADP+ + H2O
- (2) androstenedione + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] testololactone + NADP+ + H2O
- (3) 17alpha-hydroxyprogesterone + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] androstenedione + acetate + NADP+ + H2O
Ketosteroid monooxygenase is a single FAD-containing enzyme that catalyses three types of monooxygenase reaction.
References
- ↑ "A steroid ketone monooxygenase from Cylindrocarpon radicicola". Chemistry and Biochemistry of Flavoenzymes. Florida: CRC Press. 1991. pp. 102–108.
- ↑ "Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization". Journal of Biochemistry 99 (3): 815–24. March 1986. PMID 3486863.
- ↑ "Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone". Journal of Biochemistry 99 (3): 825–32. March 1986. PMID 3486864.
External links
- Ketosteroid+monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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