Biology:L-peptidase

From HandWiki
L-peptidase
Identifiers
EC number3.4.22.46
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

L-peptidase (EC 3.4.22.46) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-Gly bond. Subsequently, it cleaves host cell initiation factor eIF-4G at bonds -Gly-Arg- and -Lys-Arg-

This enzyme is coded bz foot-and-mouth disease virus.

References

  1. "Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus". Journal of Virology 69 (8): 4950–6. August 1995. PMID 7609064. 
  2. "Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes". Journal of Molecular Biology 302 (5): 1227–40. October 2000. doi:10.1006/jmbi.2000.4115. PMID 11183785. 

External links