Biology:Lactosylceramide 4-alpha-galactosyltransferase
| lactosylceramide 4-alpha-galactosyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.228 | ||||||||
| CAS number | 52725-57-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosylceramide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D- glucosylceramide
Thus, the two substrates of this enzyme are UDP-galactose and beta-D-galactosyl-(1->4)-D-glucosylceramide, whereas its 3 products are UDP, alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-, and glucosylceramide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase. Other names in common use include Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, globotriaosylceramide/CD77 synthase, and histo-blood group Pk UDP-galactose. This enzyme participates in glycosphingolipid biosynthesis - globoseries and glycan structures - biosynthesis 2.
References
- "Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney". Biochem. Biophys. Res. Commun. 141 (1): 84–91. 1986. doi:10.1016/S0006-291X(86)80338-2. PMID 3099784.
- "Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype". J. Biol. Chem. 275 (22): 16723–9. 2000. doi:10.1074/jbc.M000728200. PMID 10747952.
- "Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids". J. Biol. Chem. 275 (20): 15152–6. 2000. doi:10.1074/jbc.M909620199. PMID 10748143.
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