Biology:Lactosylceramide beta-1,3-galactosyltransferase
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Short description: Class of enzymes
| lactosylceramide beta-1,3-galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.179 | ||||||||
| CAS number | 106769-64-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a lactosylceramide beta-1,3-galactosyltransferase (EC 2.4.1.179) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R [math]\displaystyle{ \rightleftharpoons }[/math] UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R
Thus, the two substrates of this enzyme are UDP-galactose and D-galactosyl-1,4-beta-D-glucosyl-R, whereas its two products are UDP and D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase. Other names in common use include uridine diphosphogalactose-lactosylceramide, and beta1->3-galactosyltransferase.
References
- "Characterization and specific assay for a galactoside beta-3-galactosyltransferase of human kidney". Eur. J. Biochem. 173 (2): 417–22. 1988. doi:10.1111/j.1432-1033.1988.tb14015.x. PMID 3129295.
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