Biology:M7GpppX diphosphatase
From HandWiki
| M7GpppX diphosphatase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.6.1.59 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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M7GpppX diphosphatase (EC 3.6.1.59, DcpS, m7GpppX pyrophosphatase, m7GpppN m7GMP phosphohydrolase) is an enzyme with systematic name m7G5'ppp5'N m7GMP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) m7G5'ppp5'N(3'ppp5'N)n + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
- (2) 7-methylguanosine 5'-diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 7-methylguanosine 5'-phosphate + phosphate
Decapping is a process in the control of eukaryotic mRNA degradation.
References
- ↑ "Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies". Journal of Molecular Biology 363 (2): 370–82. October 2006. doi:10.1016/j.jmb.2006.08.015. PMID 16963086.
- ↑ "Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme". The Journal of Biological Chemistry 283 (24): 16427–36. June 2008. doi:10.1074/jbc.M800341200. PMID 18441014.
- ↑ "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases". The EMBO Journal 21 (17): 4699–708. September 2002. doi:10.1093/emboj/cdf448. PMID 12198172.
- ↑ "DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12081–6. October 2003. doi:10.1073/pnas.1635192100. PMID 14523240. Bibcode: 2003PNAS..10012081V.
- ↑ "Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping". Journal of Molecular Biology 347 (4): 707–18. April 2005. doi:10.1016/j.jmb.2005.01.062. PMID 15769464.
External links
- M7GpppX+diphosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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