Biology:Mannitol-1-phosphate 5-dehydrogenase
| mannitol-1-phosphate 5-dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.17 | ||||||||
| CAS number | 9028-24-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme are D-mannitol 1-phosphate and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are fructose 6-phosphate, reduced NADH and a proton.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD+ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.
See also
- D-Mannitol
References
- ↑ Enzyme 1.1.1.17 at KEGG Pathway Database.
- ↑ "Mannitol metabolism, a transferable property of pneumococcus". J. Biol. Chem. 214 (1): 383–96. 1955. doi:10.1016/S0021-9258(18)70976-9. PMID 14367396.
- ↑ Wolfe JB; Kaplan NO (1955). Wolff, Johnb; Kaplan, Nathano. eds. [46] Hexose phosphate and hexose reductase. Methods Enzymol.. 1. pp. 346–348. doi:10.1016/0076-6879(55)01050-1. ISBN 978-0-12-181801-2.
- ↑ Wolfe JB; Kaplan NO (1956). "D-Mannitol 1-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 218 (2): 849–869. doi:10.1016/S0021-9258(18)65848-X. PMID 13295236.
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