Biology:Mycothiol synthase
From HandWiki
| Mycothiol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.189 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- desacetylmycothiol + acetyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math] CoA + mycothiol
This enzyme catalyses the last step in the biosynthesis of mycothiol
References
- ↑ "Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". European Journal of Biochemistry 224 (1): 203–13. August 1994. doi:10.1111/j.1432-1033.1994.tb20013.x. PMID 8076641.
- ↑ "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes". Archives of Microbiology 178 (5): 331–7. November 2002. doi:10.1007/s00203-002-0462-y. PMID 12375100.
- ↑ "Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Science 12 (9): 1954–9. September 2003. doi:10.1110/ps.03153703. PMID 12930994.
External links
- Mycothiol+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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