Biology:Neolactotetraosylceramide alpha-2,3-sialyltransferase
| neolactotetraosylceramide alpha-2,3-sialyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.99.10 | ||||||||
| CAS number | 83745-06-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a neolactotetraosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.10) is an enzyme that catalyzes the chemical reaction
- CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D- galactosyl-1,4-D-glucosylceramide [math]\displaystyle{ \rightleftharpoons }[/math] CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
The 3 substrates of this enzyme are CMP-N-acetylneuraminate, beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-, and galactosyl-1,4-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-, and glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-neolactotetraosylceramide, sialyltransferase, sialyltransferase 3, and SAT-3. This enzyme participates in glycosphingolipid biosynthesis - neo-lactoseries and glycan structures - biosynthesis 2.
References
- "Biosynthesis in vitro of sialyl(alpha 2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain". J. Biol. Chem. 257 (21): 12765–9. 1982. PMID 7130178.
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