Biology:Nucleoporin 54
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.[1][2]
Function
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.[2]
References
- ↑ "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J Cell Biol 134 (3): 589–601. Sep 1996. doi:10.1083/jcb.134.3.589. PMID 8707840.
- ↑ 2.0 2.1 "Entrez Gene: NUP54 nucleoporin 54kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53371.
Further reading
- "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. 1999. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
- "Function and assembly of nuclear pore complex proteins". Biochem. Cell Biol. 77 (4): 321–329. 1999. doi:10.1139/bcb-77-4-321. PMID 10546895.
- "A complex of nuclear pore proteins required for pore function". J. Cell Biol. 114 (1): 169–183. 1991. doi:10.1083/jcb.114.1.169. PMID 2050741.
- "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–261. 1995. doi:10.1083/jcb.128.3.251. PMID 7531196.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex". Mol. Biol. Cell 6 (11): 1591–1603. 1996. doi:10.1091/mbc.6.11.1591. PMID 8589458.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex". J. Biol. Chem. 273 (21): 13347–13352. 1998. doi:10.1074/jbc.273.21.13347. PMID 9582382.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Nucleoporin p54
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