Biology:Nucleoporin 88

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.

Function

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.

Interactions

NUP88 has been shown to interact with NUP98.

Further reading

• "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. 1999. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558. 
• "Diverse nuclear transport pathways regulate cell proliferation and oncogenesis". Biochim. Biophys. Acta 1471 (1): M31–41. 2000. doi:10.1016/s0304-419x(00)00018-4. PMID 10967423. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32". Genomics 42 (3): 538–40. 1997. doi:10.1006/geno.1997.4767. PMID 9205132. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis". Mol. Cell. Biol. 18 (3): 1236–47. 1998. doi:10.1128/mcb.18.3.1236. PMID 9488438. 
• "The nuclear pore complex protein Nup88 is overexpressed in tumor cells". Cancer Res. 59 (21): 5408–11. 1999. PMID 10554006. 
• "A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development". Am. J. Pathol. 157 (5): 1605–13. 2000. doi:10.1016/S0002-9440(10)64798-0. PMID 11073820. 
• "Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3191–6. 2001. doi:10.1073/pnas.051631598. PMID 11248054. Bibcode: 2001PNAS...98.3191W. 
• "Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis". Hum. Pathol. 33 (5): 536–44. 2002. doi:10.1053/hupa.2002.124785. PMID 12094380. 
• "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell 14 (2): 600–10. 2003. doi:10.1091/mbc.E02-09-0582. PMID 12589057. 
• "Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer". Int. J. Cancer 109 (5): 717–20. 2004. doi:10.1002/ijc.20034. PMID 14999780. 
• "Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human tumors". Int. J. Dev. Biol. 48 (4): 339–42. 2004. doi:10.1387/ijdb.031748js. PMID 15300515. http://www.ijdb.ehu.es/web/descarga/paper/031748js. 
• "Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export". J. Biol. Chem. 281 (28): 19378–86. 2006. doi:10.1074/jbc.M512585200. PMID 16675447. 
• "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.