Biology:Nucleoporin 107
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.[1][2][3]
Function
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]
Interactions
NUP107 has been shown to interact with NUP133.[4][5]
References
- ↑ "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proceedings of the National Academy of Sciences of the United States of America 100 (3): 981–5. Feb 2003. doi:10.1073/pnas.252749899. PMID 12552102. Bibcode: 2003PNAS..100..981B.
- ↑ "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell 113 (2): 195–206. Apr 2003. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868.
- ↑ 3.0 3.1 "Entrez Gene: NUP107 nucleoporin 107kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57122.
- ↑ "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell 15 (7): 3333–44. Jul 2004. doi:10.1091/mbc.E03-12-0878. PMID 15146057.
- ↑ "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology 154 (6): 1147–60. Sep 2001. doi:10.1083/jcb.200101081. PMID 11564755.
Further reading
- "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex". The Journal of Cell Biology 137 (5): 989–1000. Jun 1997. doi:10.1083/jcb.137.5.989. PMID 9166401.
- "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology 154 (6): 1147–60. Sep 2001. doi:10.1083/jcb.200101081. PMID 11564755.
- "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". The Journal of Cell Biology 155 (3): 339–54. Oct 2001. doi:10.1083/jcb.200108007. PMID 11684705.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. Dec 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "RanGTP mediates nuclear pore complex assembly". Nature 424 (6949): 689–94. Aug 2003. doi:10.1038/nature01898. PMID 12894213. Bibcode: 2003Natur.424..689W.
- "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell 15 (7): 3333–44. Jul 2004. doi:10.1091/mbc.E03-12-0878. PMID 15146057.
- "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket". Molecular Biology of the Cell 15 (9): 4261–77. Sep 2004. doi:10.1091/mbc.E04-03-0165. PMID 15229283.
- "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex". The Journal of Cell Biology 167 (4): 591–7. Nov 2004. doi:10.1083/jcb.200408109. PMID 15557116.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. Apr 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Molecular Biology of the Cell 17 (9): 3806–18. Sep 2006. doi:10.1091/mbc.E05-11-1061. PMID 16807356.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. Oct 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proceedings of the National Academy of Sciences of the United States of America 104 (10): 3811–6. Mar 2007. doi:10.1073/pnas.0700058104. PMID 17360435. Bibcode: 2007PNAS..104.3811G.
- "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". The EMBO Journal 26 (7): 1853–64. Apr 2007. doi:10.1038/sj.emboj.7601642. PMID 17363900.
- "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex". Acta Crystallographica Section F 63 (Pt 9): 816–8. Sep 2007. doi:10.1107/S1744309107040523. PMID 17768364.
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