Biology:Oligopeptidase A

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Oligopeptidase A
Identifiers
EC number3.4.24.70
CAS number394250-11-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Oligopeptidase A (EC 3.4.24.70, 68000-M signalpeptide hydrolase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved, but not Z-(Gly)5

This enzyme is known from Escherichia coli and Salmonella typhimurium.

References

  1. "Degradation of a signal peptide by protease IV and oligopeptidase A". Journal of Bacteriology 170 (11): 5067–75. November 1988. doi:10.1128/jb.170.11.5067-5075.1988. PMID 3053642. 
  2. "Oligopeptidase A is required for normal phage P22 development". Journal of Bacteriology 174 (18): 5869–80. September 1992. doi:10.1128/jb.174.18.5869-5880.1992. PMID 1522065. 
  3. "Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene". Journal of Bacteriology 174 (18): 5881–7. September 1992. doi:10.1128/jb.174.18.5881-5887.1992. PMID 1325967. 
  4. Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium. Methods in Enzymology. 248. 1995. pp. 567–79. doi:10.1016/0076-6879(95)48036-6. 

External links