Biology:P-type Na+ transporter
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Short description: Class of enzymes
| P-type Na+ transporter | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 7.2.2.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a P-type Na+ transporter (EC 7.2.2.3) is an enzyme that catalyzes the chemical reaction
- ATP + H2O + Na+[side 1] ADP + phosphate + Na+[side 2]
The 3 substrates of this enzyme are ATP, H2O, and Na+, whereas its 3 products are ADP, phosphate, and Na+.
This enzyme belongs to the family of translocases, specifically those catalysing the translocation of inorganic cations and their chelates. The systematic name of this enzyme class is ATP phosphohydrolase (P-type, Na+-exporting).
References
- "The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane". EMBO J. 14 (16): 3870–82. 1995. doi:10.1002/j.1460-2075.1995.tb00059.x. PMID 7664728.
- "The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases". FEBS Lett. 409 (3): 325–32. 1997. doi:10.1016/S0014-5793(97)00446-8. PMID 9224683. Bibcode: 1997FEBSL.409..325C. https://dipot.ulb.ac.be/dspace/bitstream/2013/50723/1/1-s2.0-S0014579397004468-main.pdf.
- "A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore". Mol. Microbiol. 23 (6): 1107–20. 1997. doi:10.1046/j.1365-2958.1997.2951656.x. PMID 9106203.
- Saier MH Jr (1998). Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Advances in Microbial Physiology. 40. 81–136. doi:10.1016/S0065-2911(08)60130-7. ISBN 9780120277407.
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