Biology:Phosphate-transporting ATPase
From HandWiki
Short description: Class of enzymes
| phosphate transmembrane-transporting ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 7.3.2.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphate-transporting ATPase (EC 3.6.3.27) is an enzyme that catalyzes the chemical reaction
- ATP + H2O + phosphate(out) [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate + phosphate(in)
The 3 substrates of this enzyme are ATP, H2O, and phosphate, whereas its two products are ADP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (phosphate-importing). This enzyme is also called ABC phosphate transporter. This enzyme participates in abc transporters - general.
References
- "Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices". J. Biol. Chem. 267 (34): 24661–8. 1992. doi:10.1016/S0021-9258(18)35815-0. PMID 1447208.
- "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146 (4): 271–8. 1995. doi:10.1016/0923-2508(96)81050-3. PMID 7569321.
- R, Content J; Lefèvre, P; De Wit, L; Ooms, J; Peirs, P; Huygen, K; Wattiez, R; Content, J (1996). "Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter". FEBS Lett. 394 (2): 206–12. doi:10.1016/0014-5793(96)00953-2. PMID 8843165.
- Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol.. Advances in Microbial Physiology 40: 81–136. doi:10.1016/S0065-2911(08)60130-7. ISBN 978-0-12-027740-7. PMID 9889977.
- The Transporter Factsbook, Academic Press, San Diego, 1998.
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