Biology:Phosphoglucosamine mutase
In enzymology, a phosphoglucosamine mutase (EC 5.4.2.10) is an enzyme that catalyzes the chemical reaction
- alpha-D-glucosamine 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] D-glucosamine 6-phosphate
Hence, this enzyme has one substrate, alpha-D-glucosamine 1-phosphate, and one product, D-glucosamine 6-phosphate.
This enzyme belongs to the family of isomerases, specifically the phosphotransferases (α-D-phosphohexomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism.
Crystal structures of two bacterial phosphoglucosamine mutases are known (PDB entries 3I3W and 3PDK), from Francisella tularensis and Bacillus anthracis. Both share a similar dimeric quaternary structure, as well as conserved features of the active site, as found their enzyme superfamily, the α-D-phosphohexomutases.
References
- "Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli". J. Biol. Chem. 271 (1): 32–9. 1996. doi:10.1074/jbc.271.1.32. PMID 8550580.
- "The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase". J. Bacteriol. 179 (11): 3488–93. 1997. doi:10.1128/jb.179.11.3488-3493.1997. PMID 9171391.
- Tomasz A; Wu, S; Van Heijenoort, J; De Lencastre, H; Mengin-Lecreulx, D; Tomasz, A (1997). "The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase". J. Bacteriol. 179 (17): 5321–5. doi:10.1128/jb.179.17.5321-5325.1997. PMID 9286983.
- Mengin-Lecreulx D; Ferrari, P; Blanot, D; Van Heijenoort, J; Fassy, F; Mengin-Lecreulx, D (1999). "Reaction mechanism of phosphoglucosamine mutase from Escherichia coli". Eur. J. Biochem. 262 (1): 202–10. doi:10.1046/j.1432-1327.1999.00373.x. PMID 10231382.
- "Autophosphorylation of phosphoglucosamine mutase from Escherichia coli". J. Bacteriol. 182 (5): 1280–5. 2000. doi:10.1128/JB.182.5.1280-1285.2000. PMID 10671448.
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