Biology:Pitrilysin
From HandWiki
| Pitrilysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.55 | ||||||||
| CAS number | 81611-78-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pitrilysin (EC 3.4.24.55, Escherichia coli protease III, protease Pi, proteinase Pi, PTR, Escherichia coli metalloproteinase Pi) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction:
- Preferential cleavage of -Tyr16- Leu- and -Phe25- Tyr-bonds of oxidized insulin B chain. Also acts on other substrates of less than 7 kDa such as glucagon
This enzyme is present in bacteria Escherichia coli.
References
- ↑ "Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III". Nucleic Acids Research 14 (19): 7695–703. October 1986. doi:10.1093/nar/14.19.7695. PMID 3534791.
- ↑ "Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III". Science 242 (4884): 1415–8. December 1988. doi:10.1126/science.3059494. PMID 3059494. Bibcode: 1988Sci...242.1415A.
- ↑ "An unusual active site identified in a family of zinc metalloendopeptidases". Proceedings of the National Academy of Sciences of the United States of America 89 (9): 3835–9. May 1992. doi:10.1073/pnas.89.9.3835. PMID 1570301. Bibcode: 1992PNAS...89.3835B.
- ↑ "Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III". The Journal of Biological Chemistry 267 (4): 2414–20. February 1992. doi:10.1016/S0021-9258(18)45895-4. PMID 1733942.
- ↑ "Characterization of the bacterial metalloendopeptidase pitrilysin by use of a continuous fluorescence assay". The Biochemical Journal 290 ( Pt 2) (2): 601–7. March 1993. doi:10.1042/bj2900601. PMID 7680857.
External links
- Pitrilysin at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
