Biology:Poly(adp-ribose) polymerase family member 14

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene.

Function

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.