Biology:Polygalacturonate 4-alpha-galacturonosyltransferase
| polygalacturonate 4-alpha-galacturonosyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.43 | ||||||||
| CAS number | 37277-53-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a polygalacturonate 4-alpha-galacturonosyltransferase (EC 2.4.1.43) is an enzyme that catalyzes the chemical reaction
- UDP-D-galacturonate + (1,4-alpha-D-galacturonosyl)n [math]\displaystyle{ \rightleftharpoons }[/math] UDP + (1,4-alpha-D-galacturonosyl)n+1
Thus, the two substrates of this enzyme are UDP-D-galacturonate and (1,4-alpha-D-galacturonosyl)n, whereas its two products are UDP and (1,4-alpha-D-galacturonosyl)n+1.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase. Other names in common use include UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase, uridine diphosphogalacturonate-polygalacturonate, and alpha-galacturonosyltransferase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism.
Indications
Polygalacturonate salts can be used clinically to treat the GI reactions that are due to Quinidine.
References
- "Properties of a polygalacturonic acid-synthesizing enzyme system from Phaseolus aureus seedlings". Arch. Biochem. Biophys. 116 (1): 446–52. 1966. doi:10.1016/0003-9861(66)90051-8. PMID 5961848.
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