Biology:Procollagen C-endopeptidase

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Procollagen C-endopeptidase
Identifiers
EC number3.4.24.19
CAS number68651-95-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Procollagen C-endopeptidase (EC 3.4.24.19, procollagen C-terminal proteinase, carboxyprocollagen peptidase, procollagen C-terminal peptidase, procollagen C-proteinase, procollagen carboxypeptidase, procollagen carboxy-terminal proteinase, procollagen peptidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III

This endopeptidase belongs to the peptidase family M12 (astacin family).

References

  1. "Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization". The Journal of Biological Chemistry 260 (29): 15996–6003. December 1985. PMID 3905801. 
  2. "Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein". European Journal of Biochemistry 186 (1-2): 115–21. December 1989. doi:10.1111/j.1432-1033.1989.tb15184.x. PMID 2689170. 

External links