Biology:Progesterone monooxygenase

From HandWiki
Progesterone
monooxygenase
Identifiers
EC number1.14.99.4
CAS number37256-85-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Progesterone monooxygenase (EC 1.14.99.4) is an enzyme that catalyzes a chemical reaction that converts the steroid hormone, progesterone, to testosterone acetate. This is part of the mechanism that microorganisms such as Cylindrocarpon radicicola use to break down progesterone[1]

  1. REDIRECT Template:Chemical reaction

This enzyme is an oxidoreductase, that uses molecular oxygen together with an unknown electron acceptor. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating). This enzyme is also called progesterone hydroxylase.[2]

References

  1. "Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain". The Journal of Biological Chemistry 241 (15): 3615–23. August 1966. doi:10.1016/S0021-9258(18)99875-3. PMID 5950688. 
  2. Enzyme 1.14.99.4 at KEGG Pathway Database.