Biology:Protein N-acetylglucosaminyltransferase
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Short description: Class of enzymes
protein N-acetylglucosaminyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.4.1.94 | ||||||||
CAS number | 72319-34-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a protein N-acetylglucosaminyltransferase (EC 2.4.1.94) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine + protein [math]\displaystyle{ \rightleftharpoons }[/math] UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and protein, whereas its two products are UDP and 4-N-(N-acetyl-D-glucosaminyl)-protein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase. Other names in common use include uridine diphosphoacetylglucosamine-protein, acetylglucosaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide, beta-N-acetylglucosaminyltransferase, and O-GlcNAc transferase.
References
- "Glycosylation of ribonuclease A catalysed by rabbit liver extracts". Biochem. J. 146 (2): 299–307. 1975. PMID 1156375.
- "UDP-N-acetyl-D-glucosamine-asparagine sequon N-acetyl-beta-D-glucosaminyl-transferase-activity in human serum". Carbohydr. Res. 49: 455–73. 1976. doi:10.1016/S0008-6215(00)83163-8. PMID 986874.
- "Glycosylation in vitro of an asparagine sequon catalysed by preparations of yeast cell membranes". Biochem. J. 160 (1): 37–41. 1976. PMID 795426.
External links
- N-Acetylglucosaminyltransferases at the US National Library of Medicine Medical Subject Headings (MeSH)
Original source: https://en.wikipedia.org/wiki/Protein N-acetylglucosaminyltransferase.
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