Biology:Pyrimidine oxygenase
From HandWiki
| Pyrimidine oxygenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.14.99.46 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Pyrimidine oxygenase (EC 1.14.99.46, RutA) is an enzyme with systematic name uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening).[1][2] This enzyme catalyses the following chemical reaction
- (1) uracil + FMNH2 + O2 [math]\displaystyle{ \rightleftharpoons }[/math] (Z)-3-ureidoacrylate peracid + FMN
- (2) thymine + FMNH2 + O2 [math]\displaystyle{ \rightleftharpoons }[/math] (Z)-2-methylureidoacrylate peracid + FMN
In vitro the product (Z)-3-ureidoacrylate peracid is spontaneously reduced to ureidoacrylate.
References
- ↑ "Catalysis of a flavoenzyme-mediated amide hydrolysis". Journal of the American Chemical Society 132 (16): 5550–1. April 2010. doi:10.1021/ja9107676. PMID 20369853.
- ↑ "The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems". Journal of Bacteriology 192 (16): 4089–102. August 2010. doi:10.1128/JB.00201-10. PMID 20400551.
External links
- Pyrimidine+oxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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