Biology:Rhesus lymphocryptovirus

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Short description: Species of virus


Rhesus lymphocryptovirus
Virus classification e
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Genus: Lymphocryptovirus
Species:
Lymphocryptovirus macacinegamma4
Synonyms
  • Rhesus lymphocryptovirus
  • Cercopithecine herpesvirus 15
  • Macacine gammaherpesvirus 4
  • Rhesus HHV-4-like virus
  • Rhesus Epstein Barr virus
  • Rhesus EBV-like herpesvirus

Rhesus lymphocryptovirus (RLV) is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Orthoherpesviridae, and order Herpesvirales.[1][2]

In nature, RLV infects rhesus macaques (Macaca mulatta).

Comparison with Epstein-Barr virus

Its genetic structure has been fully sequenced and found to be highly homologous with that of Epstein-Barr virus (EBV), at 65%. The structural proteins are highly conserved, while genes expressed during EBV latent infection are much less well conserved. Even in cases where genes have low homology, the RLV infection genes are functionally interchangeable with EBV genes.[3]

RLV infection in rhesus monkeys resembles EBV infection in humans in several respects:

  • Oral transmission,
  • Atypical lymphocytosis
  • Lymphadenopathy
  • Activation of CD23+ peripheral blood B cells
  • Sustained serologic responses to lytic and latent Human gammaherpesvirus 4 antigens
  • Latent infection in the peripheral blood
  • Virus persistence in oropharyngeal secretions

These features make the rhesus lymphocryptovirus potentially useful for studying the pathogenesis, prevention, and treatment of EBV infection and associated oncogenesis.[4]

References

  1. ↑ "ICTV Master Species List 2018b.v2". https://talk.ictvonline.org/files/master-species-lists/m/msl/8266. 
  2. ↑ "History of the taxon: Species: Lymphocryptovirus macacinegamma4 (2023 Release, MSL #39)". International Committee on Taxonomy of Viruses. https://ictv.global/taxonomy/taxondetails?taxnode_id=202301487&taxon_name=Lymphocryptovirus%20macacinegamma4. 
  3. ↑ "Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model". J. Virol. 76 (1): 421–6. 2002. doi:10.1128/jvi.76.1.421-426.2002. PMID 11739708. 
  4. ↑ Amir Moghaddam; Michael Rosenzweig; David Lee-Parritz; Bethany Annis; R. Paul Johnson; Fred Wang (1997). "An Animal Model for Acute and Persistent Epstein-Barr Virus Infection". Science 276 (5321): 2030–2033. doi:10.1126/science.276.5321.2030. PMID 9197263. 

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