Biology:SARS coronavirus main proteinase
From HandWiki
| SARS coronavirus main proteinase | |||||||||
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 SARS main proteinase oktamer | |||||||||
| Identifiers | |||||||||
| EC number | 3.4.22.69 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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SARS coronavirus main proteinase (EC 3.4.22.69, 3cLpro, 3C-like protease, coronavirus 3C-like protease, Mpro, SARS 3C-like protease, SARS coronavirus 3CL protease, SARS coronavirus main peptidase, SARS coronavirus main protease, SARS-CoV 3CLpro enzyme, SARS-CoV main protease, SARS-CoV Mpro, severe acute respiratory syndrome coronavirus main protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
TSAVLQ-SGFRK-NH2 and SGVTFQ-!GKFKK are the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase
This cysteine protease is important in SARS coronavirus replicase polyprotein processing.
References
- ↑ "Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus". Biochemistry 46 (30): 8744–52. July 2007. doi:10.1021/bi0621415. PMID 17605471.
- ↑ "Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase". The Journal of Biological Chemistry 279 (3): 1637–42. January 2004. doi:10.1074/jbc.m310875200. PMID 14561748.
- ↑ "Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant". Bioorganic & Medicinal Chemistry 16 (21): 9400–8. November 2008. doi:10.1016/j.bmc.2008.09.057. PMID 18845442.
External links
- SARS+coronavirus+main+proteinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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