Biology:SCP2
 Generic protein structure example |
Non-specific lipid-transfer protein also known as sterol carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene.[1][2]
Function
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.[3]
Clinical significance
This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis.[3]
Interactions
SCP2 has been shown to interact with Caveolin 1[4] and peroxisomal receptor PEX5.[5]
References
- ↑ "Cloning and expression of a cDNA encoding human sterol carrier protein 2". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 463–7. January 1991. doi:10.1073/pnas.88.2.463. PMID 1703300. Bibcode: 1991PNAS...88..463Y.
- ↑ "cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21----pter". DNA Cell Biol. 10 (8): 559–69. October 1991. doi:10.1089/dna.1991.10.559. PMID 1718316.
- ↑ 3.0 3.1 "Entrez Gene: SCP2 sterol carrier protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6342.
- ↑ "Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo". Biochemistry 43 (23): 7288–306. June 2004. doi:10.1021/bi035914n. PMID 15182174. https://scholarworks.sfasu.edu/biology/44.
- ↑ "Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p". Mol. Cell 24 (5): 653–63. December 2006. doi:10.1016/j.molcel.2006.10.024. PMID 17157249.
Further reading
- "Sterol carrier protein-2". Biochim. Biophys. Acta 1486 (1): 45–54. 2000. doi:10.1016/s1388-1981(00)00047-0. PMID 10856712.
- "Gene structure, intracellular localization, and functional roles of sterol carrier protein-2". Prog. Lipid Res. 40 (6): 498–563. 2001. doi:10.1016/S0163-7827(01)00015-7. PMID 11591437.
- Yamamoto R (1993). "[Localization of human sterol carrier protein 2 gene and cDNA expression in COS-7 cell]". Hokkaido Igaku Zasshi 67 (6): 839–48. PMID 1483685.
- "Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx". DNA Cell Biol. 10 (9): 695–8. 1992. doi:10.1089/dna.1991.10.695. PMID 1755959.
- "Interaction of fluorescent delta 5,7,9(11),22-ergostatetraen-3 beta-ol with sterol carrier protein-2". J. Biol. Chem. 265 (1): 151–7. 1990. doi:10.1016/S0021-9258(19)40208-1. PMID 2294101.
- "Human sterol carrier protein x/sterol carrier protein 2 gene has two promoters". Biochemistry 34 (33): 10660–8. 1995. doi:10.1021/bi00033a042. PMID 7654720.
- "The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2)". Genomics 24 (2): 370–4. 1995. doi:10.1006/geno.1994.1630. PMID 7698762.
- "Sterol carrier protein-2 stimulates intermembrane sterol transfer by direct membrane interaction". Chem. Phys. Lipids 76 (1): 73–84. 1995. doi:10.1016/0009-3084(95)02436-M. PMID 7788802.
- "Assignment of sterol carrier protein X/sterol carrier protein 2 to 1p32 and its exclusion as the causative gene for infantile neuronal ceroid lipofuscinosis". Hum. Mol. Genet. 3 (2): 341–6. 1994. doi:10.1093/hmg/3.2.341. PMID 8004106.
- "Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity". J. Biol. Chem. 269 (33): 21277–83. 1994. doi:10.1016/S0021-9258(17)31960-9. PMID 8063752.
- "NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2". FEBS Lett. 335 (1): 18–26. 1993. doi:10.1016/0014-5793(93)80431-S. PMID 8243660.
- "Structure-activity studies of human sterol carrier protein 2". J. Biol. Chem. 269 (4): 2613–8. 1994. doi:10.1016/S0021-9258(17)41988-0. PMID 8300590.
- "Expression of sterol carrier protein 2 (SCP2) in human adrenocortical tissue". Eur. J. Endocrinol. 134 (4): 501–7. 1996. doi:10.1530/eje.0.1340501. PMID 8640304.
- "The sterol carrier protein-2 fatty acid binding site: an NMR, circular dichroic, and fluorescence spectroscopic determination". Biochemistry 36 (7): 1719–29. 1997. doi:10.1021/bi962317a. PMID 9048555.
- "Isolation and characterization of the human SCP2 cDNA and chromosomal localization of the gene". Mamm. Genome 10 (6): 642–4. 1999. doi:10.1007/s003359901062. PMID 10341103.
- "Stability and binding properties of wild-type and c17s mutated human sterol carrier protein 2". Biochim. Biophys. Acta 1432 (2): 265–74. 1999. doi:10.1016/S0167-4838(99)00114-4. PMID 10407148.
- "Lipid-binding proteins in rat and human kidney". Kidney Int. Suppl. 71: S159–62. 1999. doi:10.1046/j.1523-1755.1999.07141.x. PMID 10412765.
- "The sterol carrier protein-2 amino terminus: a membrane interaction domain". Biochemistry 38 (40): 13231–43. 1999. doi:10.1021/bi990870x. PMID 10529196.
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