Biology:Small nucleolar RNA SNORA74
From HandWiki
| Small nucleolar RNA SNORA74 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA74 | |
| Identifiers | |
| Symbol | SNORA74 |
| Alt. Symbols | U19 |
| Rfam | RF00090 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; H/ACA-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000594 |
| PDB structures | PDBe |
In molecular biology, Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing.[2][3]
References
- ↑ "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development 11 (7): 941–56. April 1997. doi:10.1101/gad.11.7.941. PMID 9106664.
- ↑ "Characterization of the intron-encoded U19 RNA, a new mammalian small nucleolar RNA that is not associated with fibrillarin". Molecular and Cellular Biology 16 (4): 1391–400. April 1996. doi:10.1128/MCB.16.4.1391. PMID 8657112.
- ↑ "Human U19 intron-encoded snoRNA is processed from a long primary transcript that possesses little potential for protein coding". RNA 4 (4): 445–54. April 1998. PMID 9630250.
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