- D-sorbitol 6-phosphate + NAD+ [math]\rightleftharpoons[/math] D-fructose 6-phosphate + NADH + H+
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.
- "The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum". Biochim. Biophys. Acta 206 (3): 333–42. 1970. doi:10.1016/0005-2744(70)90150-6. PMID 4318899.
- "D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes". J. Biol. Chem. 237: 1342–50. 1962. PMID 14465816.
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