Biology:Sorbitol-6-phosphate 2-dehydrogenase

From HandWiki
Jump to: navigation, search

In enzymology, a sorbitol-6-phosphate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NAD+ [math]\rightleftharpoons[/math] D-fructose 6-phosphate + NADH + H+

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD+, whereas its 3 products are D-fructose 6-phosphate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.


  • "The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum". Biochim. Biophys. Acta 206 (3): 333–42. 1970. doi:10.1016/0005-2744(70)90150-6. PMID 4318899. 
  • "D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes". J. Biol. Chem. 237: 1342–50. 1962. PMID 14465816. 2-dehydrogenase was the original source. Read more.